Peer-reviewed Publications
1. Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman AV, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Hynes RO, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, and Spiegelman BM. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.
Cell. 2018 Dec 13;175(7):1756-1758.
2. Islam MR, Young MF, Wrann CD. Neuroprotective potential of exercise preconditioning in stroke.
Conditioning Medicine. 2018 (in press).
3. Jedrychowski MP*, Wrann CD*, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.
Cell Metab. 2015 Oct 6;22(4):734-40. *Co-first author
Previewed in: Geach T. News: Circulating irisin confirmed by mass spectrometry. Nat Rev Endocrinol. 2015 Oct;11(10):568.
Covered in (selected): Science Translational Medicine,The Scientist, Science Daily, Reddit, Medical Daily
4. Wrann CD. FNDC5/Irisin – Their Role in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain. Brain Plasticity. 2015 (1):55–61. PMID: 28480165.
5. Laue T, Wrann CD, Hoffmann-Castendiek B, Pietsch D, Hübner L, Kielstein H. Altered NK cell function in obese healthy humans. BMC Obes. 2015 Jan 24;2:1.
6. Jahn J, Spielau M, Brandsch C, Stangl GI, Delank KS, Bähr I, Berreis T, Wrann CD, Kielstein H. Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obesity (Silver Spring). 2015 Nov; 23(11):2233-41.
7. Wahlqvist ML, Krawetz SA, Rizzo NS, Dominguez-Bello MG, Szymanski LM, Barkin S, Yatkine A, Waterland RA, Mennella JA, Desai M, Ross MG, Krebs NF, Young BE, Wardle J, Wrann CD, Kral JG. Early-life influences on obesity: from preconception to adolescence. Ann N Y Acad Sci. 2015 Jul;1347:1-28.
8. Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway. Cell Metab. 2013 Nov 5;18(5):649-59.
Previewed in: Xu B. BDNF (I)rising from Exercise. Cell Metab. 2013 Nov 5;18(5):612-4.
Covered in (selected): Science (print, online, and podcast), Nature, Huffington Post, Forbes, AlzForum, Medical Daily, EurekAlert!
9. White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proceedings of the National Academy of Sciences of the United States 2014 Nov 4;111(44):15756-61.
10. Rajesh RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera D, Lachey J, Gygi SP, Seehra J, Hawley JA, Spiegelman BM. Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell. 2014 June 5;157(6).
11. Gomes AP, Price NL, Ling AJY, Moslehi JJ, Montgomery M, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL and Sinclair DA. Declining NAD+ induces a pseudohypoxic state that disrupts nuclear-mitochondrial communication during aging. Cell. 2013 Dec 19;155(7):1624-38.
12. Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL. Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation. Am J Physiol Endocrinol Metab. 2014 Jan 15;306(2):E157-67.
13. Huebner L, Engeli S, Wrann CD, Goudeva L, Laue T, Kielstein H. Human NK cell subset functions are differentially affected by adipokines. PLoS One. 2013 Sep 30;8(9):e75703.
14. Wrann CD, Rosen ED. New insights into adipocyte-specific leptin gene expression. Adipocyte. 2012 Jul 1;1(3):168-172.
15. Wrann CD, Eguchi J, Xu Z, Mikkelsen T, Gimble J, Nave, H, Ong, S-E, Rosen ED. FOSL2 promotes human adipocyte-specific leptin gene expression. Journal of Clinical Investigation. 2012 Mar 1;122:1010-21.
16. Wrann CD*, Laue, T, Hubner, L, Kuhlmann, S, Jacobs R, Goudeva L, Nave H. Short-term and long-term leptin exposure differentially affects human Natural Killer cell immune functions. American Journal of Physiology – Endocrinology 2011 Sep 27. *Corresponding author
17. Heger CD, Wrann CD, Collins RN. Phosphorylation provides a negative mode of regulation for the yeast Rab GTPase Sec4p. PLoS One. 2011;6(9):e24332.
18. Dahlke K, Wrann CD, Sommerfeld O, Soßdorf M, Recknagel P, Sachse S, Winter SW, Klos A, Stahl GL, Ma YX, Claus RA, Reinhart K, Bauer M, Riedemann NC.Distinct Different Contributions of the Alternative and Classical Complement Activation Pathway for the Innate Host Response during Sepsis. Journal of Immunology 2011 Mar 1;186(5):3066-75.
19. Wrann CD*, Ehmer, U, Lautenbach A, Kuhlmann, S, Nave H. Obesity and NK cells affect the expression of the long-form of the leptin receptor Ob-Rb in the liver of F344 rats. Experimental and Toxicologic Pathology 2010; 62(1):1-8. *Corresponding author
20. Lautenbach A, Wrann CD, Jacobs R, Müller G, Brabant G, Nave H. Altered Phenotype of NK Cells From Obese Rats Can Be Normalized by Transfer Into Lean Animals. Obesity (Silver Spring) 2009; 17(10):1848-55.
21. Lautenbach A, Budde A, Wrann CD, Teichmann B, Vieten G, Karl T, Pabst R, Nave H. Additive effects of leptin, estrogen and IGF-I are responsible for the elevated proliferation of breast cancer cells in obesity. Nutrition and Cancer 2009; 61(4):484-91.
22. Wrann CD, Tabriz TA, Barkhausen T, Klos A, van Griensven M, Pape HC, Kendoff DO, Guo RF, Ward PA, Krettek C, Riedemann NC. The PI3K signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions. Journal of Immunology 2007;1;178:5940-8.
23. Wrann CD, Winter SW, Barkhausen T, Hildebrandt F, Krettek C, Riedemann, NC. Distinct involvement of p38-, Erk1/2 and PKC signaling pathways in C5a-mediated priming of oxidative burst in phagocytic cells. Cellular Immunology 2007;245(2):63-9.
24. Agneskirchner JD, Hurschler C, Wrann CD, Lobenhoffer P. Factors determing effective decompression of the medial compartment of the tibiofemoral joint after valgus high tibial osteotomy. Arthroscopy 2007; 23 (8):852-61.
Non-peer reviewed publications
1. Islam MR, Young MF, Wrann CD. The role of FNDC5/Irisin in the nervous system and as a mediator for beneficial effects of exercise on the brain. Hormones, Metabolism and the Benefits of Exercise. 1st ed. Springer Publishers; 2018 (in press)
2. Agneskirchner JD, Wrann CD. Der Effekt von Umstellungsosteotomien auf Knorpeldrücke. In: Philipp Lobenhoffer, Jens D Agneskirchner (editors). „Kniegelenksnahe Osteomien“ 2nd ed. Stuttgart: Thieme Medical Publishers; 2014. p. 104-15.
3. Agneskirchner JD, Wrann CD, Freiling D, Hurschler C, Lobenhoffer P. Biomech. testing of different plates.
4. Wrann CD, Lobenhoffer P, Agneskirchner JD. Effect of osteotomies on cartilage pressure in the knee.
3. Agneskirchner JD, Lobenhoffer P, Wrann CD. Osteotomy and ligament instability: tibial slope corrections and combined procedures around the knee joint.
All in: P. Lobenhoffer, RJ van Heerwaarden, AE Staubli, R.P Jakob (editors). “Osteotomies around the Knee” 1st ed. AO Foundation Publishing, Thieme; 2008.
4. Agneskirchner JD, Wrann CD. Der Effekt von Umstellungsosteotomien auf Knorpeldrucke. In: P. Loben-hoffer, JD Agneskirchner (editor). „Kniegelenksnahe Osteomien“ 1st ed. Stuttgart: Thieme; 2006. p. 11-20.
5. von Hörsten S, Hoffmann T, Alfalah M, Wrann CD, Karl T, Papst R, Bedoui S. PP, PPY, NPY: Synthesis, Storage, Release and Degradation. In: MC Michel (editor). “Neuropetide Y and Related Peptides”, 1st ed. Heidelberg: Springer; 2004. p. 23-44.